银杏叶提取物中黄酮类化合物抗肿瘤活性研究进展

张立虎, 吴婷婷, 赵林果, 萧伟, 张慎华, 王昌选, 赵祎武

中国药学杂志 ›› 2019, Vol. 54 ›› Issue (6) : 444-449.

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中国药学杂志
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中国药学杂志 ›› 2019, Vol. 54 ›› Issue (6) : 444-449. DOI: 10.11669/cpj.2019.06.003
综述

银杏叶提取物中黄酮类化合物抗肿瘤活性研究进展

  • 张立虎1,2, 吴婷婷1, 赵林果1*, 萧伟3, 张慎华3, 王昌选3, 赵祎武3
作者信息 +

Advances in Studies on Anticancer Activity of Flavonoids from Ginkgo biloba Extract

  • ZHANG Li-hu1,2, WU Ting-ting1, ZHAO Lin-guo1*, XIAO Wei3, ZHANG Shen-hua3, WANG Chang-xuan3, ZHAO Yi-wu3
Author information +
文章历史 +

摘要

银杏叶富含黄酮类、银杏内酯等具有较好药用效果的次生代谢产物,其提取物除具有显著的拮抗血小板活化因子(PAF)受体外,还具有抗炎、抗过敏、扩张血管、保护心脑血管、改善外周血液循环、降低血清胆固醇等功效,可以广泛应用于心脑血管、神经等系统疾病的防治和保健。随着银杏叶提取物化学成分及其药理学的深入研究表明,银杏黄酮还具有抗肿瘤、预防肿瘤作用,是一种很有潜力的癌症化学预防剂,能显著降低多种恶性肿瘤的发病率。笔者综述了银杏黄酮类化合物结构、抗肿瘤效应及其机制的研究进展,可为银杏深加工和新用途的开发利用提供参考和依据。

Abstract

Ginkgo biloba is a kind of ancient relict woody. It is a common homologous plant of medicine and food. Its leaves and fruits can produce secondary metabolites, such as flavonoids and ginkgolide, which have good medicinal effects. Ginkgo biloba leaves have low toxicity and broad-spectrum pharmacological activity. The research showed that ginkgo flavonoid has the effect of anticancer and cancer prevention. It is a potential chemical for cancer prophylaxis, which can significantly reduce the incidence of many malignant cancers. The progress in research on the structures, antitumor effects, and mechanism of flavonoids of Ginkgo biloba is summarized in this article, which provides a pharmacological basis for the deep processing and comprehensive utilization of Ginkgo biloba.

关键词

银杏叶提取物 / 黄酮 / 槲皮素 / 山柰酚 / 抗肿瘤

Key words

Ginkgo biloba extract / flavonoid / quercetin / kaempferol / anticancer

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张立虎, 吴婷婷, 赵林果, 萧伟, 张慎华, 王昌选, 赵祎武. 银杏叶提取物中黄酮类化合物抗肿瘤活性研究进展[J]. 中国药学杂志, 2019, 54(6): 444-449 https://doi.org/10.11669/cpj.2019.06.003
ZHANG Li-hu , WU Ting-ting , ZHAO Lin-guo , XIAO Wei , ZHANG Shen-hua , WANG Chang-xuan , ZHAO Yi-wu. Advances in Studies on Anticancer Activity of Flavonoids from Ginkgo biloba Extract[J]. Chinese Pharmaceutical Journal, 2019, 54(6): 444-449 https://doi.org/10.11669/cpj.2019.06.003
中图分类号： R979.1   

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基金

江苏省政策引导类计划资助(省苏北科技专项SZ-XZ2017023) ;林业科学技术推广项目资助(10号);江苏省青蓝工程资助(2017);江苏省高职院校青年教师企业实践项目资助(2017QYSJ035)
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